Marble Burying Test Interpretation

This test has some predictive value for anti depressant and or anxiolytic drugs.

Marble burying test interpretation.

Regardless the test is widely applied to. Mice which are placed individually in a cage bury glass marbles that are present in the cage. Marble burying the marble burying test is a useful model of neophobia 1 anxiety 1 7 and obsessive compulsive behavior 8 11. The marble burying test has been tested for the effects of the novelty of marbles by exposing animals to them in the home cage or administering the test repeatedly and neither has a pronounced effect on burying behaviour thomas et al 2009 njung e and handley 1991b homma and yamada 2009.

The marble burying test is used to record the number of marbles buried by mice placed in a novel environment. It has been shown to be sensitive to benzodiazepines as these compounds reduce burying behaviour when. It has also been proposed that the test may have predictive validity for the screening of novel antidepressants 12 15 anxiolytics 15 16 and antipsychotics 17 19. There is also a genetic component to.

Marble burying is an animal model used in scientific research to depict anxiety or obsessive compulsive disorder ocd behavior. Therefore the test serves largely as a measure. It can be weeks before a noticeable change is observed in patients. Rodent marble burying behavior in the marble burying test mbt is employed as a model or measure to study anxiety and compulsive like behaviors or anxiolytic and anticompulsive drug action.

The marble burying task can be used both as an indicator of obsessive compulsive like ocd behavior and or anxiety like behavior. The marble burying test measures one acute dose of anti anxiety agent for thirty minutes. Mice with ocd like symptoms tend to engage in a high degree of repetitive behaviors including digging. When mice are placed in a novel cage a common response is to show increased digging behavior.

Rodent marble burying behavior in the marble burying test mbt is employed as a model or measure to study anxiety and compulsive like behaviors or anxiolytic and anticompulsive drug action. While widely used there is significant controversy over the interpretation of its results. The marble burying test is commonly used to quantify anxiety obsessive compulsive or repetitive behaviour in rodents 1 3 performance on the marble burying test is also associated with general digging behaviour 4 7 and so the underlying construct being measured is still unclear regardless the typical protocol places 10 25 marbles in a cage containing sawdust or similar.